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23 years
Does genotropin (growth hormon) lead to weight gain and/or increasing insuline level? What's the relation between high insuline level and gainig weight? And how to reduce it?
May 22, 2014

Dr. Rania Mousa General Medicine
Effects of growth hormone or ( somatotropin) on the tissues of the body can generally be described as anabolic (building up). Like most other protein hormones, GH acts by interacting with a specific receptor on the surface of cells.
Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range. Growth hormone is often said to have anti-insulin activity, because it supresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver. paradoxically, administration of growth hormone stimulates insulin secretion, leading to hyperinsulinemia.
-It has an effect on the weight ,since it build muscles and increase height and it
-Increased height during childhood is the most widely known effect of GH.
-Increases calcium retention, and strengthens and increases the mineralization of bone
-Increases muscle mass through sarcomere hypertrophy
-Promotes lipolysis
-Increases protein synthesis
-Stimulates the growth of all internal organs excluding the brain
-Plays a role in homeostasis
-Reduces liver uptake of glucose
-Promotes gluconeogenesis in the liver[37]
-Contributes to the maintenance and function of pancreatic islets
-Stimulates the immune system
-Increases deiodination of T4 to T3

When you take insulin, glucose is able to enter your cells, and glucose levels in your blood drop. This is the desired therapeutic goal. However, if the number of calories you take in and your activity level result in more calories than you need to maintain a healthy weight, your cells will get more glucose than they need. Glucose that your cells don't use accumulates as fat.
Weight gain may also be related to other complex functions of insulin in the body related to how cells use fats and proteins.
What to do?
Eating healthy foods and staying physically active every day can help you prevent unwanted weight gain. The following tips can help you keep the pounds off:
1-Count calories. Eating and drinking fewer calories helps you prevent weight gain
2-Don't skip meals. Don't try to cut calories by skipping meals. When you skip a meal, your body is less efficient at using energy, and you're more likely to make poor diet choices at the next mealtime because you're too hungry
3-Be physically active. Physical activity burns calories. A reasonable goal for most adults is a minimum of 150 minutes a week of moderately intense aerobic activity — such as walking, bicycling, water aerobics, dancing or gardening — plus muscle-strengthening exercises at least two times a week.
4-Take your insulin only as directed. Don't skip or reduce your insulin dosages to ward off weight gain. Although you might shed pounds if you take less insulin than prescribed, the risks are serious. Without enough insulin, your blood sugar level will rise — and so will your risk of diabetes complications.